Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies
Identifieur interne : 000A65 ( Main/Exploration ); précédent : 000A64; suivant : 000A66Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies
Auteurs : R. Thertulien [États-Unis] ; G. M. Manikhas [Russie] ; L. Y. Dirix [Belgique] ; J. B. Vermorken [Belgique] ; K. Park [Corée du Sud] ; M. M. Jain [Inde] ; J. J. Jiao [États-Unis] ; J. Natarajan [États-Unis] ; T. Parekh [États-Unis] ; P. Zannikos [États-Unis] ; A. P. Staddon [États-Unis]Source :
- Cancer Chemotherapy and Pharmacology [ 0344-5704 ] ; 2011.
Abstract
The primary objective of this study was to access the potential effects of trabectedin on the QT/QTc interval in patients with locally advanced or metastatic solid tumors.
Patients (
The upper limits of the 90% confidence interval for ΔΔQTcF and ΔΔQTcB at all time points were less than the prespecified noninferiority margin of 10 ms (≤6.65 ms). No patient had a QTc > 500 ms or a time-matched increase from baseline in QTc > 60 ms at any time point. Regression analyses indicated ΔΔQTc was poorly correlated with trabectedin concentration. No adverse events suggestive of proarrhythmic potential were reported.
Trabectedin did not prolong the QTc interval. Safety and pharmacokinetic profiles of trabectedin were similar to that observed in other ovarian and breast cancer studies.
Url:
DOI: 10.1007/s00280-011-1697-6
PubMed: 21739119
PubMed Central: 3265736
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000139
- to stream Pmc, to step Curation: 000139
- to stream Pmc, to step Checkpoint: 000367
- to stream Ncbi, to step Merge: 000106
- to stream Ncbi, to step Curation: 000106
- to stream Ncbi, to step Checkpoint: 000106
- to stream Main, to step Merge: 000A67
- to stream Main, to step Curation: 000A65
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies</title><author><name sortKey="Thertulien, R" sort="Thertulien, R" uniqKey="Thertulien R" first="R." last="Thertulien">R. Thertulien</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Cancer Centers of North Carolina-Asheville, 20 Medical Park Drive, Asheville, NC 28803 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Cancer Centers of North Carolina-Asheville, 20 Medical Park Drive, Asheville</wicri:cityArea></affiliation></author><author><name sortKey="Manikhas, G M" sort="Manikhas, G M" uniqKey="Manikhas G" first="G. M." last="Manikhas">G. M. Manikhas</name><affiliation wicri:level="1"><nlm:aff id="Aff2">City Clinical Oncology Dispensary, St. Petersburg, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>City Clinical Oncology Dispensary, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Dirix, L Y" sort="Dirix, L Y" uniqKey="Dirix L" first="L. Y." last="Dirix">L. Y. Dirix</name><affiliation wicri:level="1"><nlm:aff id="Aff3">AZ Sint-Augustinus, Oncologisch Centrum, Wilrijk, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>AZ Sint-Augustinus, Oncologisch Centrum, Wilrijk</wicri:regionArea><wicri:noRegion>Wilrijk</wicri:noRegion></affiliation></author><author><name sortKey="Vermorken, J B" sort="Vermorken, J B" uniqKey="Vermorken J" first="J. B." last="Vermorken">J. B. Vermorken</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Universitair Ziekenhuis Antwerpen, Edegem, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Universitair Ziekenhuis Antwerpen, Edegem</wicri:regionArea><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Park, K" sort="Park, K" uniqKey="Park K" first="K." last="Park">K. Park</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Jain, M M" sort="Jain, M M" uniqKey="Jain M" first="M. M." last="Jain">M. M. Jain</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Ruby Hall Clinic, Pune, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Ruby Hall Clinic, Pune</wicri:regionArea><wicri:noRegion>Pune</wicri:noRegion></affiliation></author><author><name sortKey="Jiao, J J" sort="Jiao, J J" uniqKey="Jiao J" first="J. J." last="Jiao">J. J. Jiao</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Natarajan, J" sort="Natarajan, J" uniqKey="Natarajan J" first="J." last="Natarajan">J. Natarajan</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Parekh, T" sort="Parekh, T" uniqKey="Parekh T" first="T." last="Parekh">T. Parekh</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Zannikos, P" sort="Zannikos, P" uniqKey="Zannikos P" first="P." last="Zannikos">P. Zannikos</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Staddon, A P" sort="Staddon, A P" uniqKey="Staddon A" first="A. P." last="Staddon">A. P. Staddon</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Pennsylvania Oncology Hematology Associates, Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Pennsylvania Oncology Hematology Associates, Philadelphia</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21739119</idno><idno type="pmc">3265736</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265736</idno><idno type="RBID">PMC:3265736</idno><idno type="doi">10.1007/s00280-011-1697-6</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000139</idno><idno type="wicri:Area/Pmc/Curation">000139</idno><idno type="wicri:Area/Pmc/Checkpoint">000367</idno><idno type="wicri:Area/Ncbi/Merge">000106</idno><idno type="wicri:Area/Ncbi/Curation">000106</idno><idno type="wicri:Area/Ncbi/Checkpoint">000106</idno><idno type="wicri:doubleKey">0344-5704:2011:Thertulien R:effect:of:trabectedin</idno><idno type="wicri:Area/Main/Merge">000A67</idno><idno type="wicri:Area/Main/Curation">000A65</idno><idno type="wicri:Area/Main/Exploration">000A65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies</title><author><name sortKey="Thertulien, R" sort="Thertulien, R" uniqKey="Thertulien R" first="R." last="Thertulien">R. Thertulien</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Cancer Centers of North Carolina-Asheville, 20 Medical Park Drive, Asheville, NC 28803 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Cancer Centers of North Carolina-Asheville, 20 Medical Park Drive, Asheville</wicri:cityArea></affiliation></author><author><name sortKey="Manikhas, G M" sort="Manikhas, G M" uniqKey="Manikhas G" first="G. M." last="Manikhas">G. M. Manikhas</name><affiliation wicri:level="1"><nlm:aff id="Aff2">City Clinical Oncology Dispensary, St. Petersburg, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>City Clinical Oncology Dispensary, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Dirix, L Y" sort="Dirix, L Y" uniqKey="Dirix L" first="L. Y." last="Dirix">L. Y. Dirix</name><affiliation wicri:level="1"><nlm:aff id="Aff3">AZ Sint-Augustinus, Oncologisch Centrum, Wilrijk, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>AZ Sint-Augustinus, Oncologisch Centrum, Wilrijk</wicri:regionArea><wicri:noRegion>Wilrijk</wicri:noRegion></affiliation></author><author><name sortKey="Vermorken, J B" sort="Vermorken, J B" uniqKey="Vermorken J" first="J. B." last="Vermorken">J. B. Vermorken</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Universitair Ziekenhuis Antwerpen, Edegem, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Universitair Ziekenhuis Antwerpen, Edegem</wicri:regionArea><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Park, K" sort="Park, K" uniqKey="Park K" first="K." last="Park">K. Park</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Jain, M M" sort="Jain, M M" uniqKey="Jain M" first="M. M." last="Jain">M. M. Jain</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Ruby Hall Clinic, Pune, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Ruby Hall Clinic, Pune</wicri:regionArea><wicri:noRegion>Pune</wicri:noRegion></affiliation></author><author><name sortKey="Jiao, J J" sort="Jiao, J J" uniqKey="Jiao J" first="J. J." last="Jiao">J. J. Jiao</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Natarajan, J" sort="Natarajan, J" uniqKey="Natarajan J" first="J." last="Natarajan">J. Natarajan</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Parekh, T" sort="Parekh, T" uniqKey="Parekh T" first="T." last="Parekh">T. Parekh</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Zannikos, P" sort="Zannikos, P" uniqKey="Zannikos P" first="P." last="Zannikos">P. Zannikos</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan</wicri:cityArea></affiliation></author><author><name sortKey="Staddon, A P" sort="Staddon, A P" uniqKey="Staddon A" first="A. P." last="Staddon">A. P. Staddon</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Pennsylvania Oncology Hematology Associates, Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Pennsylvania Oncology Hematology Associates, Philadelphia</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cancer Chemotherapy and Pharmacology</title><idno type="ISSN">0344-5704</idno><idno type="eISSN">1432-0843</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>The primary objective of this study was to access the potential effects of trabectedin on the QT/QTc interval in patients with locally advanced or metastatic solid tumors.</p></sec><sec><title>Methods</title><p>Patients (<italic>n</italic> = 75) who had received ≤3 previous lines of chemotherapy and had either relapsed or had progressive disease were enrolled. Patients were administered 3-h intravenous infusions of placebo (saline) on day 1 and trabectedin (1.3 mg/m<sup>2</sup>) on day 2. Time-matched serial triplicate ECG recordings and pharmacokinetic blood samples were collected over 24 h on both days. Heart rate corrected mean QT intervals and changes from predose baseline in QTc (ΔQTc) were assessed. The difference in ΔQTc between trabectedin and placebo was calculated at each time point (ΔΔQTc).</p></sec><sec><title>Results</title><p>The upper limits of the 90% confidence interval for ΔΔQTcF and ΔΔQTcB at all time points were less than the prespecified noninferiority margin of 10 ms (≤6.65 ms). No patient had a QTc > 500 ms or a time-matched increase from baseline in QTc > 60 ms at any time point. Regression analyses indicated ΔΔQTc was poorly correlated with trabectedin concentration. No adverse events suggestive of proarrhythmic potential were reported.</p></sec><sec><title>Conclusion</title><p>Trabectedin did not prolong the QTc interval. Safety and pharmacokinetic profiles of trabectedin were similar to that observed in other ovarian and breast cancer studies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Boudou, L" uniqKey="Boudou L">L Boudou</name></author><author><name sortKey="Baconnier, M" uniqKey="Baconnier M">M Baconnier</name></author><author><name sortKey="Blay, J Y" uniqKey="Blay J">J-Y Blay</name></author><author><name sortKey="Lombard Bohas, C" uniqKey="Lombard Bohas C">C Lombard-Bohas</name></author><author><name sortKey="Cassier, Pa" uniqKey="Cassier P">PA Cassier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, Nj" uniqKey="Carter N">NJ Carter</name></author><author><name sortKey="Keam, Sj" uniqKey="Keam S">SJ Keam</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Perez Ruixo, Jj" uniqKey="Perez Ruixo J">JJ Perez-Ruixo</name></author><author><name sortKey="Zannikos, P" uniqKey="Zannikos P">P Zannikos</name></author><author><name sortKey="Hirankarn, S" uniqKey="Hirankarn S">S Hirankarn</name></author><author><name sortKey="Stuyckens, K" uniqKey="Stuyckens K">K Stuyckens</name></author><author><name sortKey="Ludwig, Ea" uniqKey="Ludwig E">EA Ludwig</name></author><author><name sortKey="Soto Matos, A" uniqKey="Soto Matos A">A Soto-Matos</name></author><author><name sortKey="Lopez Lazaro, L" uniqKey="Lopez Lazaro L">L Lopez-Lazaro</name></author><author><name sortKey="Owen, Js" uniqKey="Owen J">JS Owen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beumer, Jh" uniqKey="Beumer J">JH Beumer</name></author><author><name sortKey="Lopez Lazaro, L" uniqKey="Lopez Lazaro L">L Lopez-Lazaro</name></author><author><name sortKey="Schellens, Jh" uniqKey="Schellens J">JH Schellens</name></author><author><name sortKey="Beijnen, Jh" uniqKey="Beijnen J">JH Beijnen</name></author><author><name sortKey="Tellingen, O" uniqKey="Tellingen O">O Tellingen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vermeir, M" uniqKey="Vermeir M">M Vermeir</name></author><author><name sortKey="Hemeryck, A" uniqKey="Hemeryck A">A Hemeryck</name></author><author><name sortKey="Cuyckens, F" uniqKey="Cuyckens F">F Cuyckens</name></author><author><name sortKey="Francesch, A" uniqKey="Francesch A">A Francesch</name></author><author><name sortKey="Bockx, M" uniqKey="Bockx M">M Bockx</name></author><author><name sortKey="Houdt, J" uniqKey="Houdt J">J Houdt</name></author><author><name sortKey="Steemans, K" uniqKey="Steemans K">K Steemans</name></author><author><name sortKey="Mannens, G" uniqKey="Mannens G">G Mannens</name></author><author><name sortKey="Aviles, P" uniqKey="Aviles P">P Aviles</name></author><author><name sortKey="Coster, R" uniqKey="Coster R">R Coster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gussak, I" uniqKey="Gussak I">I Gussak</name></author><author><name sortKey="Litwin, J" uniqKey="Litwin J">J Litwin</name></author><author><name sortKey="Kleiman, R" uniqKey="Kleiman R">R Kleiman</name></author><author><name sortKey="Grisanti, S" uniqKey="Grisanti S">S Grisanti</name></author><author><name sortKey="Morganroth, J" uniqKey="Morganroth J">J Morganroth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roden, M" uniqKey="Roden M">M Roden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, Rr" uniqKey="Shah R">RR Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darpo, B" uniqKey="Darpo B">B Darpo</name></author><author><name sortKey="Nebout, T" uniqKey="Nebout T">T Nebout</name></author><author><name sortKey="Sager, Pt" uniqKey="Sager P">PT Sager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cassier, Pa" uniqKey="Cassier P">PA Cassier</name></author><author><name sortKey="Dufresne, A" uniqKey="Dufresne A">A Dufresne</name></author><author><name sortKey="Blay, Jy" uniqKey="Blay J">JY Blay</name></author><author><name sortKey="Fayette, J" uniqKey="Fayette J">J Fayette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sessa, C" uniqKey="Sessa C">C Sessa</name></author><author><name sortKey="Braud, F" uniqKey="Braud F">F Braud</name></author><author><name sortKey="Perotti, A" uniqKey="Perotti A">A Perotti</name></author><author><name sortKey="Bauer, J" uniqKey="Bauer J">J Bauer</name></author><author><name sortKey="Curigliano, G" uniqKey="Curigliano G">G Curigliano</name></author><author><name sortKey="Noberasco, C" uniqKey="Noberasco C">C Noberasco</name></author><author><name sortKey="Zanaboni, F" uniqKey="Zanaboni F">F Zanaboni</name></author><author><name sortKey="Gianni, L" uniqKey="Gianni L">L Gianni</name></author><author><name sortKey="Marsoni, S" uniqKey="Marsoni S">S Marsoni</name></author><author><name sortKey="Jimeno, J" uniqKey="Jimeno J">J Jimeno</name></author><author><name sortKey="D Ncalci, M" uniqKey="D Ncalci M">M D’Incalci</name></author><author><name sortKey="Dall, E" uniqKey="Dall E">E Dall’o</name></author><author><name sortKey="Colombo, N" uniqKey="Colombo N">N Colombo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demetri, Gd" uniqKey="Demetri G">GD Demetri</name></author><author><name sortKey="Chawla, Sp" uniqKey="Chawla S">SP Chawla</name></author><author><name sortKey="Mehren, M" uniqKey="Mehren M">M Mehren</name></author><author><name sortKey="Ritch, P" uniqKey="Ritch P">P Ritch</name></author><author><name sortKey="Baker, Lh" uniqKey="Baker L">LH Baker</name></author><author><name sortKey="Blay, Jy" uniqKey="Blay J">JY Blay</name></author><author><name sortKey="Hande, Kr" uniqKey="Hande K">KR Hande</name></author><author><name sortKey="Keohan, Ml" uniqKey="Keohan M">ML Keohan</name></author><author><name sortKey="Samuels, Bl" uniqKey="Samuels B">BL Samuels</name></author><author><name sortKey="Schuetze, S" uniqKey="Schuetze S">S Schuetze</name></author><author><name sortKey="Lebedinsky, C" uniqKey="Lebedinsky C">C Lebedinsky</name></author><author><name sortKey="Elsayed, Ya" uniqKey="Elsayed Y">YA Elsayed</name></author><author><name sortKey="Izquierdo, Ma" uniqKey="Izquierdo M">MA Izquierdo</name></author><author><name sortKey="Gomez, J" uniqKey="Gomez J">J Gomez</name></author><author><name sortKey="Park, Yc" uniqKey="Park Y">YC Park</name></author><author><name sortKey="Le Cesne, A" uniqKey="Le Cesne A">A Le Cesne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurtler, S" uniqKey="Gurtler S">S Gurtler</name></author><author><name sortKey="Goldstein, L" uniqKey="Goldstein L">L Goldstein</name></author><author><name sortKey="Delprete, S" uniqKey="Delprete S">S Delprete</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monk, Bj" uniqKey="Monk B">BJ Monk</name></author><author><name sortKey="Herzog, Tj" uniqKey="Herzog T">TJ Herzog</name></author><author><name sortKey="Kaye, Sb" uniqKey="Kaye S">SB Kaye</name></author><author><name sortKey="Krasner, Cn" uniqKey="Krasner C">CN Krasner</name></author><author><name sortKey="Vermorken, Jb" uniqKey="Vermorken J">JB Vermorken</name></author><author><name sortKey="Muggia, Fm" uniqKey="Muggia F">FM Muggia</name></author><author><name sortKey="Pujade Lauraine, E" uniqKey="Pujade Lauraine E">E Pujade-Lauraine</name></author><author><name sortKey="Lisyanskaya, As" uniqKey="Lisyanskaya A">AS Lisyanskaya</name></author><author><name sortKey="Makhson, An" uniqKey="Makhson A">AN Makhson</name></author><author><name sortKey="Rolski, J" uniqKey="Rolski J">J Rolski</name></author><author><name sortKey="Gorbounova, Va" uniqKey="Gorbounova V">VA Gorbounova</name></author><author><name sortKey="Ghatage, P" uniqKey="Ghatage P">P Ghatage</name></author><author><name sortKey="Bidzinski, M" uniqKey="Bidzinski M">M Bidzinski</name></author><author><name sortKey="Shen, K" uniqKey="Shen K">K Shen</name></author><author><name sortKey="Ngan, Hy" uniqKey="Ngan H">HY Ngan</name></author><author><name sortKey="Vergote, Ib" uniqKey="Vergote I">IB Vergote</name></author><author><name sortKey="Nam, Jh" uniqKey="Nam J">JH Nam</name></author><author><name sortKey="Park, Yc" uniqKey="Park Y">YC Park</name></author><author><name sortKey="Lebedinsky, Ca" uniqKey="Lebedinsky C">CA Lebedinsky</name></author><author><name sortKey="Poveda, Am" uniqKey="Poveda A">AM Poveda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Puchalski, Ta" uniqKey="Puchalski T">TA Puchalski</name></author><author><name sortKey="Ryan, Dp" uniqKey="Ryan D">DP Ryan</name></author><author><name sortKey="Garcia Carbonero, R" uniqKey="Garcia Carbonero R">R Garcia-Carbonero</name></author><author><name sortKey="Demetri, Gd" uniqKey="Demetri G">GD Demetri</name></author><author><name sortKey="Butkiewicz, L" uniqKey="Butkiewicz L">L Butkiewicz</name></author><author><name sortKey="Harmon, D" uniqKey="Harmon D">D Harmon</name></author><author><name sortKey="Seiden, Mv" uniqKey="Seiden M">MV Seiden</name></author><author><name sortKey="Maki, Rg" uniqKey="Maki R">RG Maki</name></author><author><name sortKey="Lopez Lazaro, L" uniqKey="Lopez Lazaro L">L Lopez-Lazaro</name></author><author><name sortKey="Jimeno, J" uniqKey="Jimeno J">J Jimeno</name></author><author><name sortKey="Guzman, C" uniqKey="Guzman C">C Guzman</name></author><author><name sortKey="Supko, Jg" uniqKey="Supko J">JG Supko</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bloomfield, Dm" uniqKey="Bloomfield D">DM Bloomfield</name></author><author><name sortKey="Kost, Jt" uniqKey="Kost J">JT Kost</name></author><author><name sortKey="Ghosh, K" uniqKey="Ghosh K">K Ghosh</name></author><author><name sortKey="Hreniuk, D" uniqKey="Hreniuk D">D Hreniuk</name></author><author><name sortKey="Hickey, La" uniqKey="Hickey L">LA Hickey</name></author><author><name sortKey="Guitierrez, Mj" uniqKey="Guitierrez M">MJ Guitierrez</name></author><author><name sortKey="Gottesdiener, K" uniqKey="Gottesdiener K">K Gottesdiener</name></author><author><name sortKey="Wagner, Ja" uniqKey="Wagner J">JA Wagner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malik, M" uniqKey="Malik M">M Malik</name></author><author><name sortKey="Hnatkova, K" uniqKey="Hnatkova K">K Hnatkova</name></author><author><name sortKey="Schmidt, A" uniqKey="Schmidt A">A Schmidt</name></author><author><name sortKey="Smetana, P" uniqKey="Smetana P">P Smetana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwamoto, M" uniqKey="Iwamoto M">M Iwamoto</name></author><author><name sortKey="Kost, Jt" uniqKey="Kost J">JT Kost</name></author><author><name sortKey="Mistry, Gc" uniqKey="Mistry G">GC Mistry</name></author><author><name sortKey="Wenning, La" uniqKey="Wenning L">LA Wenning</name></author><author><name sortKey="Breidinger, Sa" uniqKey="Breidinger S">SA Breidinger</name></author><author><name sortKey="Marbury, Tc" uniqKey="Marbury T">TC Marbury</name></author><author><name sortKey="Stone, Ja" uniqKey="Stone J">JA Stone</name></author><author><name sortKey="Gottesdiener, Km" uniqKey="Gottesdiener K">KM Gottesdiener</name></author><author><name sortKey="Bloomfield, Dm" uniqKey="Bloomfield D">DM Bloomfield</name></author><author><name sortKey="Wagner, Ja" uniqKey="Wagner J">JA Wagner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulhoven, R" uniqKey="Hulhoven R">R Hulhoven</name></author><author><name sortKey="Rosillon, D" uniqKey="Rosillon D">D Rosillon</name></author><author><name sortKey="Letiexhe, M" uniqKey="Letiexhe M">M Letiexhe</name></author><author><name sortKey="Meeus, Ma" uniqKey="Meeus M">MA Meeus</name></author><author><name sortKey="Daoust, A" uniqKey="Daoust A">A Daoust</name></author><author><name sortKey="Stockis, A" uniqKey="Stockis A">A Stockis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloomfield, Dm" uniqKey="Bloomfield D">DM Bloomfield</name></author><author><name sortKey="Krishna, R" uniqKey="Krishna R">R Krishna</name></author><author><name sortKey="Hreniuk, D" uniqKey="Hreniuk D">D Hreniuk</name></author><author><name sortKey="Hickey, L" uniqKey="Hickey L">L Hickey</name></author><author><name sortKey="Ghosh, K" uniqKey="Ghosh K">K Ghosh</name></author><author><name sortKey="Bergman, Aj" uniqKey="Bergman A">AJ Bergman</name></author><author><name sortKey="Miller, J" uniqKey="Miller J">J Miller</name></author><author><name sortKey="Gutierrez, Mj" uniqKey="Gutierrez M">MJ Gutierrez</name></author><author><name sortKey="Stoltz, R" uniqKey="Stoltz R">R Stoltz</name></author><author><name sortKey="Gottesdiener, Km" uniqKey="Gottesdiener K">KM Gottesdiener</name></author><author><name sortKey="Herman, Ga" uniqKey="Herman G">GA Herman</name></author><author><name sortKey="Wagner, Ja" uniqKey="Wagner J">JA Wagner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Silkey, M" uniqKey="Silkey M">M Silkey</name></author><author><name sortKey="Schumacher, M" uniqKey="Schumacher M">M Schumacher</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Raval, H" uniqKey="Raval H">H Raval</name></author><author><name sortKey="Caulfield, Jp" uniqKey="Caulfield J">JP Caulfield</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Corée du Sud</li><li>Inde</li><li>Russie</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>New Jersey</li><li>Pennsylvanie</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Thertulien, R" sort="Thertulien, R" uniqKey="Thertulien R" first="R." last="Thertulien">R. Thertulien</name></region><name sortKey="Jiao, J J" sort="Jiao, J J" uniqKey="Jiao J" first="J. J." last="Jiao">J. J. Jiao</name><name sortKey="Natarajan, J" sort="Natarajan, J" uniqKey="Natarajan J" first="J." last="Natarajan">J. Natarajan</name><name sortKey="Parekh, T" sort="Parekh, T" uniqKey="Parekh T" first="T." last="Parekh">T. Parekh</name><name sortKey="Staddon, A P" sort="Staddon, A P" uniqKey="Staddon A" first="A. P." last="Staddon">A. P. Staddon</name><name sortKey="Zannikos, P" sort="Zannikos, P" uniqKey="Zannikos P" first="P." last="Zannikos">P. Zannikos</name></country><country name="Russie"><noRegion><name sortKey="Manikhas, G M" sort="Manikhas, G M" uniqKey="Manikhas G" first="G. M." last="Manikhas">G. M. Manikhas</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Dirix, L Y" sort="Dirix, L Y" uniqKey="Dirix L" first="L. Y." last="Dirix">L. Y. Dirix</name></noRegion><name sortKey="Vermorken, J B" sort="Vermorken, J B" uniqKey="Vermorken J" first="J. B." last="Vermorken">J. B. Vermorken</name></country><country name="Corée du Sud"><noRegion><name sortKey="Park, K" sort="Park, K" uniqKey="Park K" first="K." last="Park">K. Park</name></noRegion></country><country name="Inde"><noRegion><name sortKey="Jain, M M" sort="Jain, M M" uniqKey="Jain M" first="M. M." last="Jain">M. M. Jain</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3265736
|texte= Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21739119" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a OpenAccessBelV2
| This area was generated with Dilib version V0.6.25. |  |